DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress-Reference-Cited by-同舟云学术

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress

Published:2017-02-28 Issue:468 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Simonson Bridget¹^ORCID,Subramanya Vinita²,Chan Mun Chun¹,Zhang Aifeng¹,Franchino Hannabeth²,Ottaviano Filomena²^ORCID,Mishra Manoj K.³,Knight Ashley C.²,Hunt Danielle²^ORCID,Ghiran Ionita²^ORCID,Khurana Tejvir S.³,Kontaridis Maria I.²,Rosenzweig Anthony¹,Das Saumya¹²^ORCID

Affiliation:

1. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

3. Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

The mTORC1 inhibitor DDiT4L prevents the increase in heart size caused by stress.

Funder

National Heart, Lung, and Blood Institute

Klarman Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.

1. The role of autophagy in the heart

2. Autophagy: an affair of the heart

3. Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

4. Nutrient signaling to mTOR and cell growth

5. Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

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