High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design-Reference-Cited by-同舟云学术

High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design

Published:2020-09-29 Issue:651 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Rosas-Lemus Monica¹²^ORCID,Minasov George¹²^ORCID,Shuvalova Ludmilla¹²^ORCID,Inniss Nicole L.¹²^ORCID,Kiryukhina Olga¹²^ORCID,Brunzelle Joseph³^ORCID,Satchell Karla J. F.¹²^ORCID

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

2. Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

3. Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, IL 60439, USA.

Abstract

Crystal structures of an mRNA-capping enzyme from SARS-CoV-2 in complex with its substrates suggest targets for drug design.

Funder

U.S. Department of Energy

National Institute of Allergy and Infectious Diseases

Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

1. COVID-19: Emergence, Spread, Possible Treatments, and Global Burden

2. An interactive web-based dashboard to track COVID-19 in real time

3. Zoonotic origins of human coronaviruses

4. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

5. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

Cited by 160 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In silico Evaluation of NO-Sartans against SARS-CoV-2;Current Drug Discovery Technologies;2024-11

2. Unraveling the structural and functional dimensions of SARS-CoV2 proteins in the context of COVID-19 pathogenesis and therapeutics;International Journal of Biological Macromolecules;2024-10

3. SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7;2024-08-30

4. Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends;Viruses;2024-08-20

5. Structural and functional insights into the 2′-O-methyltransferase of SARS-CoV-2;Virologica Sinica;2024-08