A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Author:

Ramsden Christopher E.123ORCID,Domenichiello Anthony F.14ORCID,Yuan Zhi-Xin1ORCID,Sapio Matthew R.5ORCID,Keyes Gregory S.1ORCID,Mishra Santosh K.6,Gross Jacklyn R.5,Majchrzak-Hong Sharon2,Zamora Daisy17,Horowitz Mark S.1,Davis John M.18ORCID,Sorokin Alexander V.9ORCID,Dey Amit9,LaPaglia Danielle M.5,Wheeler Joshua J.6,Vasko Michael R.10,Mehta Nehal N.9,Mannes Andrew J.5ORCID,Iadarola Michael J.5ORCID

Affiliation:

1. Lipid Mediators, Inflammation, and Pain Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 21224, USA.

2. Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20814, USA.

3. Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.

4. Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

5. Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, MD 20814, USA.

6. Department of Molecular Biomedical Sciences, NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.

7. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.

8. Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.

9. Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20814, USA.

10. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Abstract

Linoleic acid derivatives that may cause itchiness and headache pain are identified.

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute on Aging

NIH Clinical Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

1. IOM Report Relieving Pain in America: A Blueprint for Transforming Prevention Care Education and Research (Institute of Medicine of the National Academies 2011); www.ncbi.nlm.nih.gov/books/NBK914971.

2. Adult atopic dermatitis: A review;Napolitano M.;G. Ital. Dermatol. Venereol.,2016

3. Pruritus Epidemiology and Quality of Life

4. Intracellular Signaling and the Origins of the Sensations of Itch and Pain

5. Identification, isolation and characterization of epidermal lipids containing linoleic acid

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