Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection-Reference-Cited by-同舟云学术

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

Published:2012-02-21 Issue:212 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sun Yang¹,Li Chenggang¹,Shu Yuelong²,Ju Xiangwu¹,Zou Zhen¹,Wang Hongliang¹,Rao Shuan¹,Guo Feng¹,Liu Haolin¹,Nan Wenlong³,Zhao Yan¹,Yan Yiwu¹,Tang Jun¹,Zhao Chen¹,Yang Peng¹,Liu Kangtai¹,Wang Shunxin¹,Lu Huijun³,Li Xiao³,Tan Lei³,Gao Rongbao²,Song Jingdong²,Gao Xiang⁴,Tian Xinlun⁵,Qin Yingzhi⁵,Xu Kai-Feng⁵,Li Dangsheng⁶,Jin Ningyi³,Jiang Chengyu¹

Affiliation:

1. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China.

2. State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Changbai 155, Changping District, Beijing 102206, China.

3. Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China.

4. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, 22 Hankou Road, Nanjing 210093, China.

5. Peking Union Medical College Hospital, No.1 Shuaifuyuan, Beijing 100005, China.

6. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

Blocking autophagy reduces the extent of lung damage and decreases mortality in mice infected with the H5N1 strain of avian influenza.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference39 articles.

1. Human infection with highly pathogenic H5N1 influenza virus

2. Acute Respiratory Distress Syndrome and Pneumonia: A Comprehensive Review of Clinical Data

3. Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China

4. Human H5N1 influenza: Current insight into pathogenesis

5. Avian influenza H5N1: an update on molecular pathogenesis

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