The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

Author:

Sun Lifeng123ORCID,Ren Xiaomeng234,Wang I-Ching35,Pradhan Arun234ORCID,Zhang Yufang234,Flood Hannah M.23,Han Bo1,Whitsett Jeffrey A.34,Kalin Tanya V.34ORCID,Kalinichenko Vladimir V.234ORCID

Affiliation:

1. Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

2. Center for Lung Regenerative Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

3. Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

4. Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Department of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.

Abstract

An inhibitor of the transcription factor FOXM1 prevents asthma-associated signaling in mice exposed to a common airborne allergen.

Funder

American Cancer Society

National Heart, Lung, and Blood Institute

National Cancer Institute

Ministry of Science and Technology, Taiwan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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