The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice-Reference-Cited by-同舟云学术

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

Published:2017-04-18 Issue:475 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sun Lifeng¹²³^ORCID,Ren Xiaomeng²³⁴,Wang I-Ching³⁵,Pradhan Arun²³⁴^ORCID,Zhang Yufang²³⁴,Flood Hannah M.²³,Han Bo¹,Whitsett Jeffrey A.³⁴,Kalin Tanya V.³⁴^ORCID,Kalinichenko Vladimir V.²³⁴^ORCID

Affiliation:

1. Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

2. Center for Lung Regenerative Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

3. Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

4. Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Department of Life Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.

Abstract

An inhibitor of the transcription factor FOXM1 prevents asthma-associated signaling in mice exposed to a common airborne allergen.

Funder

American Cancer Society

National Heart, Lung, and Blood Institute

National Cancer Institute

Ministry of Science and Technology, Taiwan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference58 articles.

1. The genetics of asthma and allergic disease: a 21st century perspective

2. To respond or not to respond: T cells in allergic asthma

3. Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

4. Barrier Epithelial Cells and the Control of Type 2 Immunity

5. An Umbrella Review: Corticosteroid Therapy for Adults with Acute Asthma

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