A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis-Reference-Cited by-同舟云学术

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

Published:2015-07-21 Issue:386 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Zhaoyang¹²,Chen Jianquan³,Mirando Anthony J.¹³,Wang Cuicui¹⁴,Zuscik Michael J.¹,O’Keefe Regis J.¹⁵,Hilton Matthew J.¹³

Affiliation:

1. Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Department of Biology, University of Rochester, Rochester, NY 14642, USA.

3. Department of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.

4. Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA.

5. Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

NOTCH can protect joints or exacerbate joint injury depending on signal strength and duration and context.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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