Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing-Reference-Cited by-同舟云学术

Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing

Published:2017-06-13 Issue:483 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chastagner Patricia¹^ORCID,Rubinstein Eric²³^ORCID,Brou Christel¹^ORCID

Affiliation:

1. Institut Pasteur, Département “Biologie Cellulaire et Infection,” Laboratoire “Signalisation et Pathogenèse,” 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.

2. INSERM, U935, F-94807 Villejuif, France.

3. Université Paris Sud, F-94807 Villejuif, France.

Abstract

Ubiquitylation of the receptor Notch1 triggers its endocytosis by ligand- and receptor-bearing cells before it undergoes processing by ADAM10.

Funder

Fondation ARC

INCa

Institut Pasteur

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

1. From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

2. Notch and disease: A growing field

3. The Notch1 receptor is cleaved constitutively by a furin-like convertase

4. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

5. Notch ligand endocytosis: Mechanistic basis of signaling activity

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