Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors-Reference-Cited by-同舟云学术

Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors

Published:2018-03-27 Issue:523 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Miyazono Ken-ichi¹^ORCID,Moriwaki Saho¹,Ito Tomoko¹,Kurisaki Akira²³^ORCID,Asashima Makoto²,Tanokura Masaru¹^ORCID

Affiliation:

1. Laboratory of Basic Science on Healthy Longevity, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

2. Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Ibaraki 305-8560, Japan.

3. Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.

Abstract

Multiple hydrophobic patches on the surfaces of SMAD2 and SMAD3 mediate their interactions with cofactors.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.

1. TGFβ signalling in context

2. TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

3. Roles of TGF-β family signals in the fate determination of pluripotent stem cells

4. Mechanisms of TGF-β-mediated apoptosis

5. Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

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