The injury response to DNA damage in live tumor cells promotes antitumor immunity

Author:

Sriram Ganapathy1234ORCID,Milling Lauren E.14ORCID,Chen Jung-Kuei1234ORCID,Kong Yi Wen1234ORCID,Joughin Brian A.134ORCID,Abraham Wuhbet4,Swartwout Susanne1234,Handly Erika D.134ORCID,Irvine Darrell J.14567ORCID,Yaffe Michael B.12348ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

3. Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. David. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.

7. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

8. Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Inducing a DNA damage response in tumor cells ex vivo creates an immunogenic live-cell adjuvant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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