Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

Author:

Yeste Ada1,Takenaka Maisa C.1,Mascanfroni Ivan D.1,Nadeau Meghan1,Kenison Jessica E.1,Patel Bonny1,Tukpah Ann-Marcia1,Babon Jenny Aurielle B.2,DeNicola Megan2,Kent Sally C.2,Pozo David34,Quintana Francisco J.15

Affiliation:

1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Medicine, Diabetes Division, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA.

3. CABIMER–Andalusian Center for Molecular Biology and Regenerative Medicine (Consejo Superior de Investigaciones Científicas–University of Seville–Universidad Pablo de Olavide), Seville 41092, Spain.

4. Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, Seville 41009, Spain.

5. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

Abstract

Nanoparticles decrease disease severity and induce immune tolerance in a mouse model of type 1 diabetes.

Funder

NIH

Juvenile Diabetes Research Foundation

Boston Area Diabetes Endocrinology Research Center

Spanish Ministry of Economy and Competitiveness (ISCIII)

Mallinckrodt Pharmaceuticals

Coordination for the Improvement of Higher Education Personnel, Brazil

Questcor

National Multiple Sclerosis Society

The Helmsley Charitable Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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