Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Author:

Fey Dirk1,Halasz Melinda1,Dreidax Daniel2,Kennedy Sean P.1,Hastings Jordan F.3,Rauch Nora1,Munoz Amaya Garcia1,Pilkington Ruth1,Fischer Matthias456,Westermann Frank2,Kolch Walter178,Kholodenko Boris N.178,Croucher David R.139

Affiliation:

1. Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

2. Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

3. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

4. Department of Pediatric Hematology and Oncology, University Hospital Cologne, 50937 Cologne, Germany.

5. Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.

6. Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.

7. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

8. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

9. St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

Abstract

Patient-specific modeling of a cell death–promoting pathway may lead to personalized treatment strategies.

Funder

Breast Cancer Campaign UK

European Union Seventh Framework Programme

German Cancer Aid

German Ministry of Science and Education (BMBF)

Fordergesellschaft Kinderkrebs-Neuroblastom-Forschung

Science Foundation Ireland

Cancer Institute NSW

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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