Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients-Reference-Cited by-同舟云学术

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Published:2015-12-22 Issue:408 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Fey Dirk¹,Halasz Melinda¹,Dreidax Daniel²,Kennedy Sean P.¹,Hastings Jordan F.³,Rauch Nora¹,Munoz Amaya Garcia¹,Pilkington Ruth¹,Fischer Matthias⁴⁵⁶,Westermann Frank²,Kolch Walter¹⁷⁸,Kholodenko Boris N.¹⁷⁸,Croucher David R.¹³⁹

Affiliation:

1. Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

2. Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

3. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

4. Department of Pediatric Hematology and Oncology, University Hospital Cologne, 50937 Cologne, Germany.

5. Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.

6. Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.

7. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

8. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

9. St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

Abstract

Patient-specific modeling of a cell death–promoting pathway may lead to personalized treatment strategies.

Funder

Breast Cancer Campaign UK

European Union Seventh Framework Programme

German Cancer Aid

German Ministry of Science and Education (BMBF)

Fordergesellschaft Kinderkrebs-Neuroblastom-Forschung

Science Foundation Ireland

Cancer Institute NSW

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference71 articles.

1. Signal Transduction by the JNK Group of MAP Kinases

2. Phosphorylation Networks Regulating JNK Activity in Diverse Genetic Backgrounds

3. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

4. JNK-dependent Phosphorylation of c-Jun on Serine 63 Mediates Nitric Oxide-induced Apoptosis of Neuroblastoma Cells

5. Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride—A mechanism connected with activating JNK phosphorylation

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