The Ca 2+ export pump PMCA clears near-membrane Ca 2+ to facilitate store-operated Ca 2+ entry and NFAT activation-Reference-Cited by-同舟云学术

The Ca 2+ export pump PMCA clears near-membrane Ca 2+ to facilitate store-operated Ca 2+ entry and NFAT activation

Published:2019-10-08 Issue:602 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Go Christina K.¹²^ORCID,Hooper Robert¹²,Aronson Matthew R.¹^ORCID,Schultz Bryant¹,Cangoz Taha¹^ORCID,Nemani Neeharika²,Zhang Yi³,Madesh Muniswamy²^ORCID,Soboloff Jonathan¹²^ORCID

Affiliation:

1. Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

2. Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

3. Department of Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

Abstract

The Ca 2+ export pump PMCA4 unexpectedly facilitates Ca 2+ entry and NFAT activation in T cells.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

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4. ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+entry in the immune system and beyond

5. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

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