Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse-Reference-Cited by-同舟云学术

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

Published:2010-05-11 Issue:121 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Purbhoo Marco A.¹,Liu Hebin²,Oddos Stephane³⁴,Owen Dylan M.⁴,Neil Mark A. A.⁴,Pageon Sophie V.³,French Paul M. W.⁴,Rudd Christopher E.²⁵,Davis Daniel M.³

Affiliation:

1. Section of Hepatology and Gastroenterology, Department of Medicine, Medical School Building, Imperial College London, London W2 1PG, UK.

2. Cell Signaling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK.

3. Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.

4. Department of Physics, Imperial College London, London SW7 2AZ, UK.

5. Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

Abstract

Vesicles dynamically deliver the T cell adaptor protein LAT to sites of T cell signalosomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference35 articles.

1. Adaptors and Molecular Scaffolds in Immune Cell Signaling

2. Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

3. LAT

4. Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

5. Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

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