PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion-Reference-Cited by-同舟云学术

PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

Published:2015-03-31 Issue:370 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Mense Sarah M.¹,Barrows Douglas¹²,Hodakoski Cindy¹,Steinbach Nicole¹³,Schoenfeld David¹³,Su William¹,Hopkins Benjamin D.¹,Su Tao⁴,Fine Barry⁵,Hibshoosh Hanina⁴⁶,Parsons Ramon¹

Affiliation:

1. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

2. Department of Pharmacology, Columbia University, New York, NY 10032, USA.

3. Integrated Program in Cellular, Molecular, Structural, and Genetic Studies, Columbia University, New York, NY 10032, USA.

4. Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.

5. Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

6. Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

Abstract

Cancer-associated mutations in PREX2 enable cells to overcome the tumor-suppressive effects of PTEN.

Funder

National Cancer Institute

Komen Leadership

Department of Defense Breast Cancer Research Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference38 articles.

1. Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

2. Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

3. Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

4. PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration

5. Functional analysis of the protein phosphatase activity of PTEN

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