The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane-Reference-Cited by-同舟云学术

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

Published:2015-09-08 Issue:393 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Loregger Anke¹,Grandl Martina¹,Mejías-Luque Raquel¹,Allgäuer Michael¹²,Degenhart Kathrin¹,Haselmann Verena³,Oikonomou Christina⁴,Hatzis Pantelis⁴,Janssen Klaus-Peter⁵,Nitsche Ulrich⁵,Gradl Dietmar⁶,van den Broek Olaf⁷,Destree Olivier⁷,Ulm Kurt⁸,Neumaier Michael³,Kalali Behnam¹,Jung Andreas⁹,Varela Ignacio¹⁰,Schmid Roland M.²,Rad Roland²,Busch Dirk H.¹,Gerhard Markus¹

Affiliation:

1. Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich 81675, Germany.

2. Medical Department II, Technische Universität München, Munich 81675, Germany.

3. Institute for Clinical Chemistry, University Medical Centre Mannheim, Mannheim 68167, Germany.

4. Division of Molecular Biology and Genetics, Biomedical Sciences Research Center “Alexander Fleming,” Vari 16672, Greece.

5. Department of Surgery, Technische Universität München, Munich 81675, Germany.

6. Zoologisches Institut II, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany.

7. Hubrecht Institute, Utrecht 3508, the Netherlands.

8. Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich 81675, Germany.

9. Institute of Pathology, University of Munich, Munich 80337, Germany.

10. Instituto de Biomedicina y Biotecnología de Cantabria, Santander 39011, Spain.

Abstract

Cancer-associated mutations in RNF43 prevent its inhibitory actions on the Wnt–β-catenin pathway in the nucleus.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

1. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

2. Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

3. Secreted antagonists of the Wnt signalling pathway

4. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

5. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

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