Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

Author:

Milewska Aleksandra12ORCID,Falkowski Katherine2ORCID,Kulczycka Magdalena3ORCID,Bielecka Ewa3,Naskalska Antonina1ORCID,Mak Pawel4ORCID,Lesner Adam5ORCID,Ochman Marek6ORCID,Urlik Maciej6,Diamandis Elftherios78910ORCID,Prassas Ioannis810,Potempa Jan211,Kantyka Tomasz312ORCID,Pyrc Krzysztof1ORCID

Affiliation:

1. Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.

2. Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.

3. Laboratory of Proteolysis and Post-translational Modification of Proteins, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.

4. Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7 St., 30-387 Krakow, Poland.

5. Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

6. Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.

7. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

8. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.

9. Department of Clinical Biochemistry, University Health Network, Toronto, Canada.

10. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

11. Centre for Oral Health and Systemic Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.

12. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.

Abstract

The protease kallikrein 13 cleaves the spike protein of the human coronavirus HKU1 to facilitate viral entry.

Funder

National Science Center, Poland

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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