Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and alleviates pregnancy loss

Author:

Li Yanhong123,Zhang Jiayuan4,Zhang Di123,Hong Xiaowu5,Tao Yu1,Wang Songcun123,Xu Yuanyuan1,Piao Hailan1,Yin Weijie4,Yu Min16,Zhang Yin17,Fu Qiang1,Li Dajin123,Chang Xing4ORCID,Du Meirong123ORCID

Affiliation:

1. Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.

2. Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.

3. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China.

4. Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

5. Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

6. In Vitro Fertilization–Embryo Transfer Center, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.

7. Department of Obstetrics, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.

Abstract

A subset of natural killer cells suppresses the mother’s immune system to protect the fetus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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