Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression

Author:

Engelmann David1,Pützer Brigitte M.1

Affiliation:

1. Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany.

Abstract

Truncated variants of the p53 family alter the tumor microenvironment to promote tumor vascularization, growth, and metastasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference45 articles.

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2. Uncovering the role of p53 splice variants in human malignancy: A clinical perspective;Surget S.;Onco Targets Ther.,2013

3. p63, a Story of Mice and Men

4. DNp73 a matter of cancer: Mechanisms and clinical implications;Buhlmann S.;Biochim. Biophys. Acta,2008

5. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis

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