Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l -DOPA–Induced Dyskinesia-Reference-Cited by-同舟云学术

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Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l -DOPA–Induced Dyskinesia

Published:2009-07-21 Issue:80 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Santini Emanuela¹,Heiman Myriam²,Greengard Paul²,Valjent Emmanuel¹³⁴⁵,Fisone Gilberto¹²

Affiliation:

1. Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.

2. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.

3. INSERM, UMR-S839, 75005 Paris, France.

4. Université Pierre et Marie Curie, 75005 Paris, France.

5. Institut du Fer à Moulin, 75005 Paris, France.

Abstract

Dyskinetic side effects of a Parkinson’s disease medication may involve dopamine D1 receptor–mediated activation of mTORC1.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

1. Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

2. Dopamine dysregulation of movement control in l-DOPA-induced dyskinesia

3. Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors

4. Parkinson's disease: Levodopa‐induced dyskinesia and signal transduction

5. D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Results from a Switch in the Regulation of ERK1/2/MAP Kinase

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1. Metformin and the PI3K/AKT signaling pathway: implications for cancer, cardiovascular, and central nervous system diseases;Naunyn-Schmiedeberg's Archives of Pharmacology;2024-09-03

2. Rewarding properties of L-Dopa in experimental parkinsonism are mediated by sensitized dopamine D1 receptors in the dorsal striatum;Molecular Psychiatry;2024-09-03

3. A2AR antagonists triggered the AMPK/m-TOR autophagic pathway to reverse the calcium-dependent cell damage in 6-OHDA induced model of PD;Neurochemistry International;2024-09

4. Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior;Frontiers in Neuroscience;2024-08-30

5. Neuroinflammation and Dyskinesia: A Possible Causative Relationship?;Brain Sciences;2024-05-20

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