Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

Author:

Makarenkova Helen P.12,Hoffman Matthew P.3,Beenken Andrew4,Eliseenkova Anna V.4,Meech Robyn25,Tsau Cindy1,Patel Vaishali N.3,Lang Richard A.6,Mohammadi Moosa4

Affiliation:

1. The Neurobiology Department, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. The Neurosciences Institute, San Diego, CA 92121, USA.

3. Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

4. Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

5. Department of Clinical Pharmacology, Flinders University, Bedford Park, South Australia 5042, Australia.

6. The Visual Systems Group, Department of Ophthalmology and Division of Developmental Biology, Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA.

Abstract

Manipulation of the interaction of a morphogen with the extracellular matrix changes its biological activities by altering its diffusion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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