The mode of agonist binding to a G protein–coupled receptor switches the effect that voltage changes have on signaling-Reference-Cited by-同舟云学术

The mode of agonist binding to a G protein–coupled receptor switches the effect that voltage changes have on signaling

Author:

Rinne Andreas¹,Mobarec Juan Carlos²,Mahaut-Smith Martyn³,Kolb Peter²,Bünemann Moritz⁴

Affiliation:

1. Department of Cardiovascular Physiology, Ruhr University Bochum, Universitätsstr. 150, D-44780 Bochum, Germany.

2. Department of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, D-35032 Marburg, Germany.

3. Department of Cell Physiology and Pharmacology, University of Leicester, University Road, P. O. Box 138, Leicester LE1 9HN, UK.

4. Department of Pharmacology and Clinical Pharmacy, Philipps University Marburg, Karl-von-Frisch-Str. 1, D-35043 Marburg, Germany.

Abstract

Whether changes in membrane potential enhance or inhibit GPCR signaling depends on the binding position of the ligand.

Funder

German Research Foundation (DFG)

FoRUM

COST

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

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