Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

Author:

Ziarek Joshua J.1ORCID,Kleist Andrew B.1ORCID,London Nir2,Raveh Barak3,Montpas Nicolas45ORCID,Bonneterre Julien45,St-Onge Geneviève5,DiCosmo-Ponticello Crystal J.6ORCID,Koplinski Chad A.1,Roy Ishan7,Stephens Bryan8,Thelen Sylvia9,Veldkamp Christopher T.10,Coffman Frederick D.11,Cohen Marion C.6ORCID,Dwinell Michael B.7,Thelen Marcus9,Peterson Francis C.1ORCID,Heveker Nikolaus45,Volkman Brian F.1ORCID

Affiliation:

1. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

2. Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

3. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec H3T 1C5, Canada.

5. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.

6. Rutgers Graduate School of Biomedical Sciences, Newark, NJ 07101, USA.

7. Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

8. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 93093, USA.

9. Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vela 6, Bellinzona CH-6500, Switzerland.

10. Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, WI 53190, USA.

11. Department of Pathology and Laboratory Medicine and Center for Biophysical Pathology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Abstract

Structural analysis of the interactions between a receptor and monomeric or dimeric forms of its ligand may aid in drug design.

Funder

National Institutes of Health

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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