De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling-Reference-Cited by-同舟云学术

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

Published:2017-01-17 Issue:462 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Philipsen Lars¹,Reddycherla Amarendra V.¹,Hartig Roland¹,Gumz Janine¹,Kästle Matthias¹,Kritikos Andreas¹,Poltorak Mateusz P.¹,Prokazov Yury²,Turbin Evgeny²,Weber André²,Zuschratter Werner²,Schraven Burkhart¹³,Simeoni Luca¹,Müller Andreas J.¹⁴

Affiliation:

1. Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

2. Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany.

3. Department of Immune Control, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

4. Intravital Microscopy in Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Abstract

The tyrosine kinase Lck must undergo both conformational opening and phosphorylation to transduce signals from the T cell receptor.

Funder

Deutsche Forschungsgemeinschaft

BMBF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference42 articles.

1. Profound block in thymocyte development in mice lacking p56lck

2. Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 lck

3. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

4. T Cell Activation

5. Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

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