Loss of MCU prevents mitochondrial fusion in G 1 -S phase and blocks cell cycle progression and proliferation-Reference-Cited by-同舟云学术

Loss of MCU prevents mitochondrial fusion in G 1 -S phase and blocks cell cycle progression and proliferation

Published:2019-04-30 Issue:579 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Koval Olha M.¹^ORCID,Nguyen Emily K.¹,Santhana Velarchana¹,Fidler Trevor P.²³^ORCID,Sebag Sara C.¹,Rasmussen Tyler P.¹^ORCID,Mittauer Dylan J.¹,Strack Stefan⁴^ORCID,Goswami Prabhat C.⁵,Abel E. Dale¹²^ORCID,Grumbach Isabella M.¹²⁵⁶^ORCID

Affiliation:

1. Abboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

2. Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

3. Department of Molecular Medicine, Columbia University Medical Center, New York, NY 10032, USA.

4. Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

5. Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.

6. Veterans Affairs Healthcare System, Iowa City, IA 52246, USA.

Abstract

The mitochondrial Ca 2+ uniporter enables ATP production to match energy demands during the cell cycle.

Funder

NIH Office of the Director

U.S. Department of Veterans Affairs

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.