The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors-Reference-Cited by-同舟云学术

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

Published:2018-09-11 Issue:547 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hagenbeek Thijs J.¹^ORCID,Webster Joshua D.²,Kljavin Noelyn M.³^ORCID,Chang Matthew T.⁴,Pham Trang¹,Lee Ho-June¹^ORCID,Klijn Christiaan⁴^ORCID,Cai Allen G.¹^ORCID,Totpal Klara⁵,Ravishankar Buvana⁶,Yang Naiying⁵^ORCID,Lee Da-Hye⁷,Walsh Kevin B.³^ORCID,Hatzivassiliou Georgia⁶,de la Cruz Cecile C.⁵,Gould Stephen E.⁵,Wu Xiumin⁸,Lee Wyne P.⁸,Yang Shuqun⁹,Zhang Zhixiang⁹^ORCID,Gu Qingyang⁹,Ji Qunsheng⁹,Jackson Erica L.¹,Lim Dae-Sik⁷,Dey Anwesha¹^ORCID

Affiliation:

1. Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.

3. Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.

4. Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.

5. Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.

6. Department of Cancer Immunotherapy, Genentech Inc., South San Francisco, CA 94080, USA.

7. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.

8. Department of Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.

9. Oncology Business Unit, Research Service Division, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai 200131, China.

Abstract

Transcriptional cofactors YAP and TAZ have distinct roles in promoting proinflammatory cytokine production and tumorigenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference38 articles.

1. Management of hepatocellular carcinoma

2. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

3. The Hippo Signaling Pathway in Development and Cancer

4. Expression of Yes-associated protein in common solid tumors

5. The Hippo pathway and human cancer

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