The VDAC2-BAK Rheostat Controls Thymocyte Survival-Reference-Cited by-同舟云学术

The VDAC2-BAK Rheostat Controls Thymocyte Survival

Published:2009-08-25 Issue:85 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ren Decheng¹,Kim Hyungjin¹,Tu Ho-Chou¹,Westergard Todd D.¹,Fisher Jill K.²,Rubens Jeff A.²,Korsmeyer Stanley J.²,Hsieh James J.-D.¹,Cheng Emily H.-Y.¹³

Affiliation:

1. Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

The relative abundance of an anion channel and a proapoptotic protein determines thymocyte responses to death signals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference35 articles.

1. Cell Death

2. Apoptosis in the Pathogenesis and Treatment of Disease

3. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

4. BCL-2 in the crosshairs: tipping the balance of life and death

5. Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

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