Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production-Reference-Cited by-同舟云学术

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

Published:2017-03-28 Issue:472 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Meier Jeremy A.¹²^ORCID,Hyun Moonjung²^ORCID,Cantwell Marc¹²,Raza Ali²³^ORCID,Mertens Claudia⁴,Raje Vidisha²^ORCID,Sisler Jennifer²,Tracy Erin⁵^ORCID,Torres-Odio Sylvia⁶,Gispert Suzana⁶,Shaw Peter E.⁷,Baumann Heinz⁵,Bandyopadhyay Dipankar⁸,Takabe Kazuaki²³⁹¹⁰^ORCID,Larner Andrew C.²^ORCID

Affiliation:

1. Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298, USA.

2. Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

3. Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

4. Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10065, USA.

5. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

6. Experimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.

7. School of Life Sciences, University of Nottingham, Nottingham, U.K.

8. Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

9. Division of Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

10. Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.

Abstract

Stress depletes STAT3 in the mitochondria, and restoration of this STAT3 pool suppresses stress-induced ROS production.

Funder

National Cancer Institute

National Institute of General Medical Sciences

National Center for Advancing Translational Sciences

British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference82 articles.