The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1-Reference-Cited by-同舟云学术

The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1

Author:

Carpentier Samuel J.¹^ORCID,Ni Minjian²^ORCID,Duggan Jeffrey M.²³^ORCID,James Richard G.⁴⁵,Cookson Brad T.¹⁶,Hamerman Jessica A.²³^ORCID

Affiliation:

1. Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

2. Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA.

3. Department of Immunology, University of Washington, Seattle, WA 98109, USA.

4. Seattle Children’s Research Institute, Seattle, WA 98101, USA.

5. Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.

6. Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

Abstract

The PI3K signaling adaptor BCAP limits inflammasome activation by interacting with the caspase-1 inhibitor Flightless-1.

Funder

National Heart, Lung, and Blood Institute

National Cancer Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

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