Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2-Reference-Cited by-同舟云学术

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

Published:2018-11-13 Issue:556 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu JingJing¹^ORCID,Zou Xianlin¹^ORCID,Gotoh Tetsuya¹,Brown Anne M.²,Jiang Liang¹^ORCID,Wisdom Esther L.¹^ORCID,Kim Jae Kyoung³^ORCID,Finkielstein Carla V.¹^ORCID

Affiliation:

1. Integrated Cellular Responses Laboratory, Department of Biological Sciences, Biocomplexity Institute, Virginia Tech, Blacksburg, VA, USA.

2. Research and Informatics, University Libraries, Virginia Tech, Blacksburg, VA, USA.

3. Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

Abstract

The oncoprotein and E3 ubiquitin ligase MDM2 ubiquitylates and promotes the degradation of the circadian clock component PER2.

Funder

National Science Foundation

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference81 articles.

1. The circadian clock and cell cycle: interconnected biological circuits

2. Circadian rhythms from multiple oscillators: lessons from diverse organisms

3. Molecular Components of the Mammalian Circadian Clock

4. PAS is a dimerization domain common to Drosophila Period and several transcription factors

5. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2

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