Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection-Reference-Cited by-同舟云学术

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Published:2009-12-08 Issue:100 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zernecke Alma¹²,Bidzhekov Kiril¹,Noels Heidi¹,Shagdarsuren Erdenechimeg¹,Gan Lin³,Denecke Bernd³,Hristov Mihail¹,Köppel Thomas⁴,Jahantigh Maliheh Nazari¹,Lutgens Esther¹⁵,Wang Shusheng⁶,Olson Eric N.⁶,Schober Andreas¹,Weber Christian¹⁵

Affiliation:

1. Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

2. Rudolf-Virchow-Center–DFG Research Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.

3. Interdisciplinary Centre for Clinical Research BIOMAT, Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.

4. Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.

5. Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.

6. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

Abstract

Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Death by design: apoptosis, necrosis and autophagy

2. Apoptotic cell removal in development and tissue homeostasis

3. Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals

4. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

5. Inflammation in atherosclerosis

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