α-Synuclein Promotes Neuroprotection Through NF-κB–Mediated Transcriptional Regulation of Protein Kinase Cδ-Reference-Cited by-同舟云学术

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α-Synuclein Promotes Neuroprotection Through NF-κB–Mediated Transcriptional Regulation of Protein Kinase Cδ

Published:2011-10-18 Issue:195 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Aoki Reina¹²,Li Yun Rose¹³²

Affiliation:

1. The authors are graduate students in the Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

2. These authors contributed equally to this manuscript.

3. Medical Scientist Training Program and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference13 articles.

1. Current understanding and management of Parkinson disease: Five new things

2. Genome-wide association study reveals genetic risk underlying Parkinson's disease

3. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

4. α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

5. Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cδ Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

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3. Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration;European Journal of Neuroscience;2021-05-13

4. Maladaptive regeneration — the reawakening of developmental pathways in NASH and fibrosis;Nature Reviews Gastroenterology & Hepatology;2020-10-13

5. Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson's disease therapy;Biomaterials Science;2020

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