Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration-Reference-Cited by-同舟云学术

Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration

Published:2016-02-09 Issue:414 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Locard-Paulet Marie¹²,Lim Lindsay¹,Veluscek Giulia²,McMahon Kelly²,Sinclair John¹,van Weverwijk Antoinette³,Worboys Jonathan D.¹²,Yuan Yinyin⁴,Isacke Clare M.³,Jørgensen Claus¹²

Affiliation:

1. Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

2. Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

3. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

4. Centre for Evolution and Cancer and Centre for Molecular Pathology, Division of Molecular Pathology, The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK.

Abstract

Mass spectrometry reveals an EPHA2-based mechanism for the regulation of metastatic cancer cell extravasation.

Funder

CRUK Career Establishment Award

Wellcome Trust Studentship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference77 articles.

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2. Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis