Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation-Reference-Cited by-同舟云学术

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

Published:2020-07-21 Issue:641 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sloutsky Roman¹^ORCID,Dziedzic Noelle¹²^ORCID,Dunn Matthew J.¹,Bates Rachel M.¹,Torres-Ocampo Ana P.¹²^ORCID,Boopathy Sivakumar³^ORCID,Page Brendan¹^ORCID,Weeks John G.¹,Chao Luke H.³⁴^ORCID,Stratton Margaret M.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.

2. Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.

3. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Department of Genetics Harvard Medical School, Boston, MA 02115, USA.

Abstract

Structural and functional analyses suggest that the hub domain of CaMKII regulates kinase activity.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference53 articles.

1. Neuronal CaMKII acts as a structural kinase

2. Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

3. Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

4. The isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

5. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

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