Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAF V600E in Human Melanoma-Reference-Cited by-同舟云学术

Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAF V600E in Human Melanoma

Published:2012-01-10 Issue:206 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Biechele Travis L.¹²,Kulikauskas Rima M.²,Toroni Rachel A.²,Lucero Olivia M.²,Swift Reyna D.²,James Richard G.¹,Robin Nick C.¹,Dawson David W.³,Moon Randall T.¹,Chien Andy J.¹²

Affiliation:

1. Department of Pharmacology, Howard Hughes Medical Institute, and the Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.

2. Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA.

3. Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

The functional crosstalk between Wnt/β-catenin and BRAF signaling may yield more effective therapies for treating melanoma.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference52 articles.

1. Mutations of the BRAF gene in human cancer

2. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

3. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

4. PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

5. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors.

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