Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

Author:

Ding Yinyuan123,Huang Linzhang4,Xian Xunde12,Yuhanna Ivan S.4,Wasser Catherine R.12,Frotscher Michael5,Mineo Chieko4,Shaul Philip W.4,Herz Joachim12678

Affiliation:

1. Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.

2. Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.

3. Key Laboratory of Medical Electrophysiology, Ministry of Education of China, and the Institute of Cardiovascular Research, Sichuan Medical University, Luzhou 646000, China.

4. Center for Pulmonary and Vascular Biology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.

5. Zentrum für Molekulare Neurobiologie Hamburg, Falkenried 94, 20251 Hamburg, Germany.

6. Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.

7. Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA.

8. Center for Neuroscience, Department of Neuroanatomy, Albert-Ludwigs-University, 79104 Freiburg, Germany.

Abstract

Reelin in the circulation promotes vascular inflammation and atherosclerosis.

Funder

NIH

Hertie Foundation

American Health Assistance Foundation

Consortium for Frontotemporal Dementia Research

BrightFocus Foundation

Lupe Murchison Foundation

Ted Nash Long Life Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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