T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation-Reference-Cited by-同舟云学术

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

Published:2013-02-19 Issue:263 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Stirnweiss Anja¹,Hartig Roland¹,Gieseler Steffi¹,Lindquist Jonathan A.¹,Reichardt Peter¹,Philipsen Lars¹,Simeoni Luca¹,Poltorak Mateusz¹,Merten Camilla¹,Zuschratter Werner²,Prokazov Yury²,Paster Wolfgang³,Stockinger Hannes³,Harder Thomas¹,Gunzer Matthias¹,Schraven Burkhart¹⁴

Affiliation:

1. Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

2. Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany.

3. Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Center for Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Lazarettgasse 19, A-1090 Vienna, Austria.

4. Department of Immune Control, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Abstract

T cell activation involves the conformational activation of the tyrosine kinase Lck.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. Profound block in thymocyte development in mice lacking p56lck

2. T cell receptor signalling

3. Structures of Src-family tyrosine kinases

4. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

5. The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

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