CD45 functions as a signaling gatekeeper in T cells

Author:

Courtney Adam H.12ORCID,Shvets Alexey A.3,Lu Wen1,Griffante Gloria4ORCID,Mollenauer Marianne5,Horkova Veronika6ORCID,Lo Wan-Lin1ORCID,Yu Steven5,Stepanek Ondrej6ORCID,Chakraborty Arup K.378910ORCID,Weiss Arthur15ORCID

Affiliation:

1. Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.

3. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Division of Molecular Immunology, Department of Internal Medicine, University Hospital Erlangen and Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany.

5. Howard Hughes Medical Institute (HHMI), San Francisco, CA 94143, USA.

6. Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague 4, Czech Republic.

7. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

9. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.

10. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

CD45 promotes strong but suppresses weak antigen-induced T cell receptor activation.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Cancer Research Institute

Czech Science Foundation

German research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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