Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Author:

Civciristov Srgjan1ORCID,Ellisdon Andrew M.2ORCID,Suderman Ryan3ORCID,Pon Cindy K.1ORCID,Evans Bronwyn A.1,Kleifeld Oded24ORCID,Charlton Steven J.56ORCID,Hlavacek William S.3ORCID,Canals Meritxell1ORCID,Halls Michelle L.1ORCID

Affiliation:

1. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

2. Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

3. Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

4. Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 3200003, Israel.

5. Cell Signalling Research Group, School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.

6. Excellerate Bioscience Ltd, MediCity, Nottingham NG90 6BH, UK.

Abstract

Ultralow ligand concentrations stimulate GPCR signaling that is distinct from that elicited by high concentrations of ligand.

Funder

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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