The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy-Reference-Cited by-同舟云学术

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

Published:2011-07-19 Issue:182 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sundaresan Nagalingam R.¹,Pillai Vinodkumar B.¹,Wolfgeher Don²,Samant Sadhana¹,Vasudevan Prabhakaran³,Parekh Vishwas³,Raghuraman Hariharasundaram⁴,Cunningham John M.³,Gupta Madhu⁵,Gupta Mahesh P.¹

Affiliation:

1. Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

2. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.

3. Department of Pediatrics, Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA.

4. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

5. Department of Physiology and Biophysics, University of Illinois, Chicago, IL 60607, USA.

Abstract

Deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. PI3K: Downstream AKTion Blocks Apoptosis

2. AKT/PKB Signaling: Navigating Downstream

3. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

4. Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

5. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

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