DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination-Reference-Cited by-同舟云学术

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

Published:2010-11-02 Issue:146 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Du Zhanwen¹²,Song Jing³,Wang Yong¹²,Zhao Yiqing¹²,Guda Kishore²⁴⁵,Yang Shuming⁶,Kao Hung-Ying⁷,Xu Yan⁶⁸,Willis Joseph²⁹,Markowitz Sanford D.²⁴⁵,Sedwick David²⁴,Ewing Robert M.¹³,Wang Zhenghe¹²¹⁰

Affiliation:

1. Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.

2. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

3. Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.

4. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

5. Howard Hughes Medical Institute, Cleveland, OH 44106, USA.

6. Cancer Pharmacology Core Facility, Case Western Reserve University, Cleveland, OH 44106, USA.

7. Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.

9. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

10. Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Abstract

Degradation of a DNA methyltransferase implicated in cancer is determined by its acetylation status.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference33 articles.

1. Perceptions of epigenetics

2. Phenotypic plasticity and the epigenetics of human disease

3. The Epigenomics of Cancer

4. Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1

5. UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

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