LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s-Reference-Cited by-同舟云学术

LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s

Published:2011-03-15 Issue:164 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Wan Mei¹,Li Jun¹²,Herbst Katie³,Zhang Jin³,Yu Bing¹,Wu Xiangwei¹²,Qiu Tao¹,Lei Weiqi¹,Lindvall Charlotta²,Williams Bart O.²,Ma Hairong¹,Zhang Fengjie¹²,Cao Xu¹

Affiliation:

1. Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Shihezi Medical College, Shihezi University, Xinjiang 832002, China.

3. Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

The receptor LRP6 associates with Gα s to promote cAMP signaling by various GPCRs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.

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3. Seven transmembrane receptors: Something old, something new.;Lefkowitz R. J.;Acta Physiol.,2007

4. A G protein–linked receptor for parathyroid hormone and parathyroid hormone–related peptide.;Jüppner H.;Science,1991

5. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.;Abou-Samra A. B.;Proc. Natl. Acad. Sci. U.S.A.,1992

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