Probing the mutational landscape of regulators of G protein signaling proteins in cancer-Reference-Cited by-同舟云学术

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Probing the mutational landscape of regulators of G protein signaling proteins in cancer

Published:2020-02-04 Issue:617 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

DiGiacomo Vincent¹^ORCID,Maziarz Marcin¹,Luebbers Alex¹^ORCID,Norris Jillian M.¹,Laksono Pandu¹,Garcia-Marcos Mikel¹^ORCID

Affiliation:

1. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

Abstract

Cancer-associated mutations in RGS proteins impair their ability to inhibit G protein signaling.

Funder

National Institute of Mental Health

American Cancer Society

National Institute of General Medical Sciences

Hartwell Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference95 articles.

1. Medicine: a Signal Award for Discovering G Proteins

2. G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

3. The Molecular Basis of G Protein–Coupled Receptor Activation

4. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

5. The druggable genome

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1. Get Ready to Sharpen Your Tools: A Short Guide to Heterotrimeric G Protein Activity Biosensors;Molecular Pharmacology;2024-07-11

2. Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP;Structure;2024-01

3. Characterization of the Prognosis and Tumor Microenvironment of Cellular Senescence-related Genes through scRNA-Seq and Bulk RNA-Seq Analysis in GC;Recent Patents on Anti-Cancer Drug Discovery;2023-10-03

4. Fatty acid metabolism is related to the immune microenvironment changes of gastric cancer and RGS2 is a new tumor biomarker;Frontiers in Immunology;2022-12-14

5. Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis;Molecular Pharmacology;2022-11-16

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