Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling-Reference-Cited by-同舟云学术

Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Published:2019-04-16 Issue:577 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Xie Jiji¹^ORCID,Han Xuemei²,Zhao Chensi³,Canonigo-Balancio Ann J.¹^ORCID,Yates John R.²^ORCID,Li Yingqiu³,Lillemeier Björn F.⁴,Altman Amnon¹^ORCID

Affiliation:

1. Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

2. Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou 510006, China.

4. Nomis Center for Immunobiology and Microbial Pathogenesis & Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

The phosphotyrosine-binding domain of PKCθ interacts with the kinase Zap70 and is required for early TCR signaling.

Funder

NIH NCI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference70 articles.

1. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

2. PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors

3. The Yin and Yang of Protein Kinase C-theta (PKCθ)

4. Selective modulation of protein kinase C-Θ during T-cell activation

5. Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

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