Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors-Reference-Cited by-同舟云学术

Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors

Published:2019-09-10 Issue:598 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Fisher Jonathan¹²^ORCID,Sharma Roshan²³,Don Dilu Wisidagamage¹^ORCID,Barisa Marta¹^ORCID,Hurtado Marina Olle¹^ORCID,Abramowski Pierre¹,Porter Lucy¹^ORCID,Day William⁴,Borea Roberto¹^ORCID,Inglott Sarah⁵,Anderson John¹⁴^ORCID,Pe’er Dana²⁶^ORCID

Affiliation:

1. UCL/GOSH Institute of Child Health, Cancer Section, 30 Guilford Street, London WC1N 1EH, UK.

2. Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY 10027, USA.

4. UCL Cancer Institute, 72 Huntley St., Fitzrovia, London WC1E 6AG, UK.

5. Department of Haematology and Oncology, Great Ormond Street Hospital, London WC1N 3JH, UK.

6. Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Changing the type of T cell used to generate CAR-T cells avoids the deleterious effects of antigen-independent signaling.

Funder

NIH Office of the Director

Wellcome Trust

Action Medical Research

NIHR Clinical Research Network Thames Valley and South Midlands

Cancer Center Support

GOSHCC

Dr. Mildred Scheel Foundation for Cancer Research and the German Cancer Aid

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference69 articles.

1. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

2. Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

3. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

4. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

5. CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

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