Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression-Reference-Cited by-同舟云学术

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Published:2019-08-13 Issue:594 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Adib Rozita¹^ORCID,Montgomery Jessica M.¹^ORCID,Atherton Joseph²^ORCID,O’Regan Laura¹,Richards Mark W.³^ORCID,Straatman Kees R.⁴^ORCID,Roth Daniel⁵^ORCID,Straube Anne⁵^ORCID,Bayliss Richard³^ORCID,Moores Carolyn A.²^ORCID,Fry Andrew M.¹^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

2. Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.

3. Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

4. Centre for Core Biotechnology Services, University of Leicester, University Road, Leicester LE1 7RH, UK.

5. Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

Abstract

NEK family kinases target EML4 to ensure faithful chromosome alignment during metaphase.

Funder

Wellcome Trust

Worldwide Cancer Research

Medical Research Council

Biotechnology and Biological Sciences Research Council

Cancer Research UK

Lister Institute of Preventive Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference59 articles.

1. MICROTUBULE POLYMERIZATION DYNAMICS

2. Microtubules: greater than the sum of the parts

3. Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment

4. Regulation of microtubule dynamic instability

5. Control of microtubule organization and dynamics: two ends in the limelight

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