Identification of human immune cell subtypes most responsive to IL-1β–induced inflammatory signaling using mass cytometry

Author:

Kothari Hema12ORCID,Williams Corey M.34,McSkimming Chantel1,Drago Fabrizio1ORCID,Marshall Melissa A.1,Garmey James1ORCID,Vigneshwar Mythili1ORCID,Zunder Eli R.3ORCID,McNamara Coleen A.12ORCID

Affiliation:

1. Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.

2. Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

3. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

4. Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

The subtypes and markers of human immune cells with the greatest inflammatory response to IL-1β are identified.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

American Heart Association

FUNDING

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference94 articles.

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4. Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

5. In the eye of the storm: Immune-mediated toxicities associated with CAR-T cell therapy;Garcia Borrega J.;Hema,2019

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