A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers-Reference-Cited by-同舟云学术

A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

Published:2020-06-02 Issue:634 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Poirier Bruno¹^ORCID,Briand Veronique¹^ORCID,Kadereit Dieter²,Schäfer Matthias³,Wohlfart Paulus³^ORCID,Philippo Marie-Claire¹,Caillaud Dominique¹^ORCID,Gouraud Laurent¹^ORCID,Grailhe Patrick¹,Bidouard Jean-Pierre¹^ORCID,Trellu Marc⁴,Muslin Anthony J.⁵,Janiak Philip¹,Parkar Ashfaq A.⁶^ORCID

Affiliation:

1. Diabetes and Cardiovascular Research, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly Mazarin, France.

2. Medicinal Chemistry, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main,, Germany.

3. Diabetes and Cardiovascular Research, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926 Frankfurt am Main, Germany.

4. Drug Metabolism and Pharmacokinetics, Sanofi R&D, 1 Avenue Pierre Brossolette, 91385 Chilly-Mazarin, France.

5. Diabetes and Cardiovascular Research, Sanofi US Services, 640 Memorial Drive, Cambridge, MA 02139, USA.

6. Diabetes and Cardiovascular Research, Sanofi US Services, 55 Corporate Drive, Bridgewater, NJ 08807, USA.

Abstract

A biased S1P 1 agonist that preserves endothelial function without causing lymphopenia is identified.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

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2. Obstructive Coronary Atherosclerosis and Ischemic Heart Disease: An Elusive Link!

3. Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options

4. Direct Assessment of Coronary Steal and Associated Changes of Collateral Hemodynamics in Chronic Total Coronary Occlusions

5. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

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