YAP-mediated mechanotransduction determines the podocyte’s response to damage

Author:

Rinschen Markus M.1234ORCID,Grahammer Florian56,Hoppe Ann-Kathrin12ORCID,Kohli Priyanka123,Hagmann Henning12ORCID,Kretz Oliver567,Bertsch Sabine12,Höhne Martin1234ORCID,Göbel Heike8,Bartram Malte P.12,Gandhirajan Rajesh Kumar1,Krüger Marcus23,Brinkkoetter Paul-Thomas12,Huber Tobias B.56910,Kann Martin12,Wickström Sara A.311ORCID,Benzing Thomas1234ORCID,Schermer Bernhard1234ORCID

Affiliation:

1. Department of Internal Medicine II, University of Cologne, Cologne, Germany.

2. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

3. Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne, Germany.

4. Systems Biology of Ageing Cologne, University of Cologne, Cologne, Germany.

5. Department of Medicine IV, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

6. III. Medical Clinic and Polyclinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

7. Department of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

8. Institute of Pathology, University of Cologne, Cologne, Germany.

9. BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany.

10. Center for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Freiburg, Germany.

11. Skin Homeostasis and Ageing, Paul Gerson Unna Research Group, Max Planck Institute for Biology of Ageing, Cologne, Germany.

Abstract

Mechanosensitive activation of YAP is an early response in damaged kidneys.

Funder

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Else Kröner-Fresenius-Stiftung

BMBF

H2020

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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