Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo-Reference-Cited by-同舟云学术

Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo

Published:2019-03-26 Issue:574 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Itoh Katsuhiko¹²^ORCID,Kondoh Gen³^ORCID,Miyachi Hitoshi³^ORCID,Sugai Manabu⁴⁵,Kaneko Yoshiyuki¹,Kitano Satsuki³^ORCID,Watanabe Hitomi³^ORCID,Maeda Ryota⁶,Imura Akihiro⁶,Liu Yu¹⁷^ORCID,Ito Chizuru⁸,Itohara Shigeyoshi⁹^ORCID,Toshimori Kiyotaka⁸¹⁰,Fujita Jun¹¹¹

Affiliation:

1. Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

2. Division of Medical Equipment Management, Department of Patient Safety, Kyoto University Hospital, Kyoto 606-8507, Japan.

3. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

4. Department of Molecular Genetics, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

5. Life Science Innovation Center, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

6. Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

7. Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

8. Department of Functional Anatomy, Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

9. Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako 351-0198, Japan.

10. Future Medical Research Center, Chiba University, Chiba 260-8670, Japan.

11. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Abstract

Sperm maturation requires keeping protamine 2 dephosphorylated to enable tight DNA packaging.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

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2. Molecular control of rodent spermatogenesis

3. Mechanisms of spermiogenesis and spermiation and how they are disturbed

4. Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics

5. Epigenetic regulation of the histone-to-protamine transition during spermiogenesis

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