NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop-Reference-Cited by-同舟云学术

NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop

Published:2019-04-30 Issue:579 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

DeFelice Mialy M.¹^ORCID,Clark Helen R.²³^ORCID,Hughey Jacob J.¹^ORCID,Maayan Inbal¹^ORCID,Kudo Takamasa⁴^ORCID,Gutschow Miriam V.¹^ORCID,Covert Markus W.¹^ORCID,Regot Sergi²³⁵^ORCID

Affiliation:

1. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

2. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

5. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

The kinase IRAK1 senses the cytokine load to prevent overstimulation of the immune system.

Funder

NIH Office of the Director

NSF Office of the Director

Jerome Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference60 articles.

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5. Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

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